In vivo anti-inflammatory effect of root of Ampelocissus indica (L.) Planch (Chembravalli)

Abstract

Ampelocissus indica (L.) Planch, Vitaceae locally known as Chembravalli, is medicinal plant used for inflammatory skin ailments and documented in Hortus Malabaricus, and traditional Ayurveda books. The objective of the study is to conduct acute toxicity of root of A. indica and to evaluate its anti-inflammatory activity. Acute toxicity of A. indica was conducted as per OECD-425.Decoction of A. indica (AI-8.64ml/kg, AI-4.32ml/kg) and ethanolic extract (AIE-500mg/kg) were orally given to rats with Carrageenan induced rat paw edema and also in other rats with Cotton pellet induced granuloma; paw volume, weight of granuloma, histopathology, serum TNF_α and IL1β were assessed. Oral administration of decoction AI-8.64ml/kg, AI-4.32ml/kg, and AIE-500mg/kg significantly reduced inflammation by reducing paw volume, serum TNF_α and IL-1β.AI-8.64ml/kg reduced significantly weight of granuloma and serum TNF α, IL1β. No acute toxicity was found up to 2000mg/kg. The present finding suggested that A. indica has a protective effect on experimental inflammation in rats.